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The Association between Platelet Distribution Width and Stroke in Atrial Fibrillation Patients

Qing-Shan Lyu1, Bin Liu1, Cheng Huang2

  • 1Department of Cardiology, the Central hospital of Yongzhou, Yongzhou, Hunan, China.

Annals of Clinical and Laboratory Science
|March 1, 2019
PubMed

Insights

Platelet distribution width (PDW) is a significant risk factor for stroke in patients with atrial fibrillation (AF). Higher PDW levels may help predict stroke risk in this population.

Area of Science:

  • Cardiology
  • Hematology
  • Neurology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke.
  • Identifying reliable biomarkers for stroke prediction in AF patients is crucial for effective prevention strategies.

Purpose of the Study:

  • To investigate the association between platelet distribution width (PDW) and the occurrence of stroke in patients diagnosed with atrial fibrillation (AF).

Main Methods:

  • A cohort of 150 AF patients was analyzed, categorized into groups based on stroke occurrence (n=50) and absence of stroke (n=100).
  • Statistical analyses included multivariate logistic regression and receiver operating characteristic (ROC) curve analysis to assess PDW's predictive value.

Main Results:

  • Significant differences in systolic blood pressure, total cholesterol, C-reactive protein, and PDW were observed between the stroke and non-stroke groups (P<0.05).
  • Multivariate logistic regression identified PDW as a significant independent risk factor for stroke in AF patients, with an odds ratio (OR) of 1.56 (P=0.002).

Conclusions:

  • Platelet distribution width (PDW) is demonstrated as an important risk factor for stroke in the context of atrial fibrillation.
  • PDW shows potential as a novel and accessible biomarker for predicting stroke risk in AF patients.
Abstract

Keywords:
atrial fibrillation (AF)platelet distribution width (PDW)stroke

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