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Updated: Jan 28, 2026

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
Published on: March 3, 2014
Gold-Plated Electrode with High Scratch Strength for Electrophysiological Recordings
Mohaddeseh Vafaiee1, Manouchehr Vossoughi2,3, Raheleh Mohammadpour1
1Institute for Nanoscience and Nanotechnology, Sharif university of Technology, Tehran, Iran.
Abstract:
Multi electrode arrays (MEA) have been exploited in different electrophysiological applications. In neurological applications, MEAs are the vital interfaces between neurons and the electronic circuits with dual role; transmitting electric signal to the neurons and converting neural activity to the electric signal. Since the performance of the electrodes has a direct effect on the quality of the recorded neuronal signal, as well as the stimulation, the true choice of electrode material for MEA is crucial. Gold is one of the best candidates for fabrication of MEAs due to its high electrical conductivity, biocompatibility and good chemical stability. However, noble metals such as gold do not adhere well to the glass substrate. Consequently while exposing to the water, gold films are damaged, which impose limitations in the exploiting of gold thin films as the electrode. In this paper, a simple and cost effective method for the fabrication of gold electrode arrays is proposed. Using various mechanical (adhesion test and scratch strength), morphological (AFM and SEM) and electrochemical methods, the fabricated electrodes are characterized. The results show that the fabricated electrode arrays have significantly high scratch strength and stability within the aqueous medium. In addition, the electrical properties of the electrodes have been improved. The proposed electrodes have the potential to be exploited in other applications including electronics, electrochemistry, and biosensors.
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