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Oxidative Stress and Bronchopulmonary Dysplasia: Evidences From Microbiomics, Metabolomics, and Proteomics

Letizia Capasso1, Giovanni Vento2, Cristina Loddo3

  • 1Neonatology, Section of Pediatrics, Department of Translational Sciences, University of Naples Federico II, Naples, Italy.

Frontiers in Pediatrics
|March 1, 2019
PubMed

Insights

Bronchopulmonary dysplasia (BPD) in premature infants is linked to oxidative stress. New "omics" research, including microbiomics, metabolomics, and proteomics, offers insights into BPD

Area of Science:

  • Neonatal Medicine
  • Pediatric Respiratory Medicine
  • Biochemistry

Background:

  • Bronchopulmonary dysplasia (BPD) significantly impacts premature infant survival and health.
  • Premature infants are highly vulnerable to oxidative stress, a key factor in BPD development.
  • Oxidative stress patterns are evident in early-stage BPD, highlighting its pathogenic role.

Purpose of the Study:

  • To review emerging evidence from "omics" research in BPD.
  • To explore the relationship between microbiomics, metabolomics, proteomics, oxidative stress, and BPD pathogenesis.
  • To identify potential avenues for improved BPD prevention and treatment strategies.

Main Methods:

  • Literature review focusing on recent "omics" studies in BPD research.
  • Analysis of data linking oxidative stress markers with BPD.
  • Synthesis of findings from microbiomics, metabolomics, and proteomics.

Main Results:

  • "Omics" technologies are providing novel insights into BPD.
  • Specific oxidation patterns in infants suggest a critical role for oxidative stress in BPD pathogenesis.
  • Emerging data highlight the interconnectedness of microbial, metabolic, and protein profiles with oxidative stress in BPD.

Conclusions:

  • Oxidative stress is a crucial component in the pathogenesis of bronchopulmonary dysplasia.
  • Microbiomics, metabolomics, and proteomics offer promising new perspectives on BPD.
  • Further research integrating "omics" data is essential for developing effective BPD management strategies.

Keywords:
bronchopulmonary dysplasiametabolomicsmicrobiomicsnewbornoxidative stresspretermproteomics

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