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Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through

Jing Sun1, Suzhi Liu2, Zongxin Ling3

  • 1Department of Neurology , the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , Zhejiang 325027 , China.

Journal of Agricultural and Food Chemistry
|March 1, 2019
PubMed

Insights

Prebiotic fructooligosaccharides (FOS) improve cognition and reduce Alzheimer's disease pathology by modulating gut bacteria and the gut microbiota-GLP-1/GLP-1R pathway.

Area of Science:

  • Neuroscience
  • Microbiology
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is linked to changes in gut microbiota.
  • Prebiotics like fructooligosaccharides (FOS) can regulate gut bacteria.
  • Understanding FOS's protective mechanisms against AD is crucial.

Purpose of the Study:

  • To investigate the protective effects of FOS against Alzheimer's disease (AD) in a mouse model.
  • To explore the underlying mechanisms involving gut microbiota modulation and the GLP-1/GLP-1R pathway.

Main Methods:

  • Administered FOS to male APP/PS1 transgenic mice for 6 weeks.
  • Assessed cognitive function, amyloid deposition, synaptic plasticity markers (PSD-95, synapsin I), and JNK phosphorylation.
  • Analyzed gut microbial composition using 16S rRNA sequencing.
  • Measured gut glucagon-like peptide-1 (GLP-1) and brain GLP-1 receptor (GLP-1R) levels.

Main Results:

  • FOS treatment improved cognitive deficits and reduced amyloid pathology in transgenic mice.
  • FOS upregulated synaptic plasticity markers (synapsin I, PSD-95) and decreased JNK phosphorylation.
  • FOS altered gut microbial composition towards a healthier state.
  • FOS increased GLP-1 levels in the gut and affected GLP-1R levels in the brain.

Conclusions:

  • Fructooligosaccharides (FOS) demonstrate beneficial effects in an Alzheimer's disease mouse model.
  • FOS exerts neuroprotection by regulating gut microbiota composition.
  • The gut microbiota-GLP-1/GLP-1R signaling pathway is a key mechanism for FOS's therapeutic action in AD.
Keywords:
Alzheimer’s diseasecognitive deficitsfructooligosaccharidesgut microbiotasynaptic plasticity

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