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Erectile dysfunction in patients with haemophilia
Ming Yang1, Haowei Linda Sun2, Shannon C Jackson1,3
1British Columbia Provincial Bleeding Disorders Program - Adult Division, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Summary
Erectile dysfunction (ED) symptoms are common in patients with haemophilia (PWH), especially older individuals. Further research is needed to understand the causes and implications of ED in this population.
Area of Science:
- Hematology
- Urology
- Cardiology
Background:
- Patients with haemophilia (PWH) are living longer due to advanced treatments.
- Ageing-related health issues are emerging in PWH, including erectile dysfunction (ED).
- ED is understudied in PWH despite its impact on well-being and potential to predict cardiac events.
Purpose of the Study:
- To determine the prevalence of ED in PWH.
- To identify risk factors associated with ED in this cohort.
- To utilize the International Index of Erectile Function (IIEF) for assessment.
Main Methods:
- Prospective study involving PWH of all severities.
- Administration of the validated IIEF questionnaire.
- Collection of data on cardiovascular risk factors, surgeries, infections, medications, and haemophilia-specific factors.
- Laboratory tests (renal function, lipids, glucose, CRP), blood pressure, anthropometrics, and endothelial function (FMD, VTI) were assessed.
Main Results:
- 44 PWH completed the IIEF; median age was 49 years.
- 38.6% of participants reported ED symptoms.
- No significant difference in endothelial function (FMD, VTI) between those with and without ED.
- IIEF score correlated with age in multivariable analysis.
Conclusions:
- ED symptoms are prevalent in PWH, particularly in older patients.
- The underlying causes of ED in PWH require further investigation.
- Larger observational studies are recommended to explore ED in PWH.
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