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Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
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Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

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A Relationship Between O-Serotype, Antibiotic Susceptibility and Biofilm Formation in Uropathogenic Escherichia coli

Arezoo Noie Oskouie1, Alka Hasani1, Mohammad Ahangarzadeh Rezaee1

  • 11 Infectious and Tropical Diseases Research Center and Department of Medical Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, The Islamic Republic of Iran.

Microbial Drug Resistance (Larchmont, N.Y.)
|March 1, 2019
PubMed

Insights

Uropathogenic Escherichia coli (UPEC) infections are common in women and show resistance to antibiotics like cefotaxime. Specific UPEC serogroups, particularly O25, are linked to biofilm formation and antibiotic resistance, highlighting the need for targeted interventions.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Research

Background:

  • Uropathogenic Escherichia coli (UPEC) is a significant pathogen causing urinary tract infections (UTIs).
  • UPEC exhibits antimicrobial resistance and forms biofilms, complicating treatment.
  • Specific UPEC O-serogroups are frequently associated with UTIs and biofilm formation.

Purpose of the Study:

  • To investigate antibiotic susceptibility, biofilm formation, and serotypes of UPEC isolates.
  • To correlate UPEC characteristics with demographic data and patient comorbidities.
  • To identify key UPEC serogroups and their associated features.

Main Methods:

  • Antibiotic susceptibility testing using the Kirby-Bauer method.
  • Phenotypic and molecular assessment of biofilm formation.
  • Serotyping of UPEC isolates via multiplex PCR.

Main Results:

  • Most UPEC isolates were resistant to cefotaxime, ceftazidime, and tetracycline, but sensitive to imipenem.
  • Serogroups O25, O15, and O8 were the most prevalent and showed high biofilm production.
  • Serogroups O75 and O21 were associated with diabetes and renal disease, respectively.

Conclusions:

  • UTI incidence in women warrants attention due to high UPEC prevalence.
  • The O25 serogroup is linked to specific antibiotic resistance patterns and significant biofilm formation.
  • Serogroup characteristics are closely related to UPEC virulence factors and clinical presentation.
Keywords:
O-serotypeantibiotic susceptibilitybiofilmbiofilm-associated genesurinary tract infection

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