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Updated: Jan 28, 2026
07:45
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
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Periodic repolarization dynamics as a risk predictor after myocardial infarction: Prospective validation study.
Konstantinos D Rizas1, Angela J Doller2, Wolfgang Hamm1
1Medizinische Klinik und Poliklinik I, University Hospital Munich, Ludwig-Maximilians University, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany.
Heart Rhythm
|March 1, 2019
Summary
Periodic repolarization dynamics (PRD) predicts death after myocardial infarction (MI). Increased PRD signifies higher total and cardiovascular mortality risk in MI survivors, even with modern treatments.
Area of Science:
- Cardiology
- Electrocardiography
- Cardiac Electrophysiology
Background:
- Periodic repolarization dynamics (PRD) quantifies sympathetic activity-associated cardiac repolarization.
- Prior studies suggest elevated PRD correlates with post-myocardial infarction (MI) mortality risk.
Purpose of the Study:
- To prospectively validate PRD as a predictor of mortality in contemporary MI patients.
- To assess the independent prognostic value of PRD in this population.
Main Methods:
- 455 MI survivors (age ≤80) in sinus rhythm were enrolled.
- PRD assessed via 20-min ECG; dichotomized at 5.75 deg².
- Multivariable Cox regression included GRACE score, LVEF, diabetes, and deceleration capacity.
Main Results:
- Increased PRD was significantly associated with total and cardiovascular mortality (AUCs 69.3% and 79.1%, respectively; P < .001).
- Increased PRD indicated a 2.2-fold risk of total mortality (P=.024) and 9.5-fold risk of cardiovascular mortality (P=.003).
- PRD addition improved mortality prediction models.
Conclusions:
- PRD is a strong, independent predictor of mortality post-MI.
- PRD offers valuable prognostic information in patients receiving current therapies.
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