How structure informs and transforms chemogenetics
Related Experiment Video
Updated: Jan 28, 2026

Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
Published on: June 7, 2018
1Department of Pharmacology and Division of Medicinal Chemistry and Chemical Biology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC 27514, United States.
Abstract:
Chemogenetic technologies such as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are widely used to remotely control neuronal and non-neuronal signaling. DREADDs exist for most of the canonical G protein-coupled receptor signaling pathways, and provide a synthetic biology platform useful for elucidating the role of neuronal signaling for brain function. Here, a focused review is provided that shows how recent insights obtained from GPCR structural studies inform our understanding of these chemogenetic tools from a structural perspective.
More Related Videos
07:12Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
Published on: July 1, 2014
08:37Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
Published on: December 22, 2020
Related Concept Videos
Bacterial Transformation
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Transformation
Transformers
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
The Ideal Transformer
Ampere's Law forms the basis of understanding the magnetic field within the transformer. It states that the integral of the magnetic field intensity's tangential...
Properties of the z-Transform II
Moreover, the convolution property indicates that the convolution of two signals in the time domain corresponds to the product of their z-transforms in the frequency...
Three-Winding Transformers
In the per-unit equivalent circuit of a grounded Y-Y three-phase...