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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with

Huan Liu1, Yongnan Lyu2, Di Li1

  • 1Dept of Clinical Laboratory, Wuhan Univ, Renmin Hospital, Jiefang Road 238, Wuhan, 430060, Hubei, China.

Cardiovascular Diabetology
|March 2, 2019
PubMed
Abstract

Insights

In male patients with coronary artery disease (CAD), higher levels of Growth Differentiation Factor-15 (GDF-15) were linked to lower testosterone. This suggests GDF-15 may play a role in CAD progression alongside testosterone deficiency.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Inflammation Biology

Background:

  • Coronary artery disease (CAD) development involves interactions between inflammation and endocrine disorders.
  • Growth Differentiation Factor-15 (GDF-15) is implicated in CAD.
  • Testosterone's effects on CAD are considered anti-atherosclerotic.

Purpose of the Study:

  • To investigate the association between serum GDF-15 and testosterone levels in male patients diagnosed with CAD.

Main Methods:

  • Serum GDF-15 and testosterone concentrations were measured in 426 male CAD patients and 220 male controls.
  • Hs-CRP and other baseline characteristics were also assessed.

Main Results:

  • CAD patients exhibited higher GDF-15 and lower testosterone levels compared to controls (p < 0.001).
  • Low testosterone levels correlated with elevated GDF-15 (p < 0.001).
  • High GDF-15 was independently associated with testosterone deficiency in male CAD patients via regression analysis.

Conclusions:

  • Elevated GDF-15 levels are associated with testosterone deficiency in male CAD patients.
  • Upregulation of GDF-15 with low testosterone may be a mechanism influencing CAD progression.
Keywords:
Coronary artery diseaseGrowth differentiation factor-15Testosterone

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