Related Experiment Video
Updated: Jan 28, 2026
Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
Published on: February 23, 2024
Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes
J D Baal1, W C Chen2, D A Solomon3
1From the Departments of Radiology and Biomedical Imaging (J.D.B., J.E.V.-M.).
Background And Purpose:
Chordoid meningiomas are uncommon WHO grade II primary intracranial neoplasms that possess unique chordoid histology and follow an aggressive clinical course. Our aim was to assess the utility of qualitative MR imaging features and quantitative apparent diffusion coefficient values as distinguishing preoperative MR imaging metrics to identify and differentiate chordoid histology from other meningioma histologic subtypes.
Materials And Methods:
Twenty-one patients with meningiomas with chordoid histology, which included both chordoid meningiomas (>50% chordoid histology) and meningiomas with focal chordoid histology (<50% chordoid histology) with available preoperative MR imaging examinations, including diffusion-weighted imaging, were identified. Qualitative imaging features and quantitative ADC values were compared between meningiomas with chordoid histology and 42 nonchordoid meningiomas (29 WHO grade I, eleven WHO grade II, and 2 WHO grade III).
Results:
The median ADC (10-3mm2/s) of meningiomas with chordoid histology was significantly higher than nonchordoid meningiomas (1.16 versus 0.92, P < .001), as was the median normalized ADC (1.60 versus 1.19, P < .001). In subgroup analysis, the median and normalized ADC values of chordoid meningiomas (n = 11) were significantly higher than those in meningiomas with focal chordoid histology (n = 10, P < .001 and P < .001, respectively) or nonchordoid meningiomas (n = 42, P < .001 and <0.001, respectively). Median and normalized ADC values were not significantly different between the meningiomas with focal chordoid histology and nonchordoid meningiomas (P = .816 and .301, respectively). Among the qualitative imaging features, only DWI signal intensity was significantly associated with meningiomas with chordoid histology diagnosis.
Conclusions:
ADC values are higher in chordoid compared with nonchordoid meningiomas and may be used to discriminate the degree of chordoid histology in meningiomas. While qualitative MR imaging features do not strongly discriminate chordoid from nonchordoid meningiomas, DWI may allow preoperative identification of chordoid meningiomas.
Insights
Apparent diffusion coefficient (ADC) values are higher in chordoid meningiomas than nonchordoid types. Diffusion-weighted imaging (DWI) may help differentiate these aggressive brain tumors preoperatively.
Area of Science:
- Neurosurgery
- Radiology
- Oncology
Background:
- Chordoid meningiomas are rare WHO grade II intracranial tumors with aggressive behavior.
- Distinguishing chordoid histology preoperatively is crucial for treatment planning.
Purpose of the Study:
- To evaluate MR imaging features for differentiating chordoid meningiomas from other subtypes.
- To assess the utility of apparent diffusion coefficient (ADC) values and qualitative imaging features.
Main Methods:
- Retrospective analysis of 21 patients with chordoid meningiomas and 42 nonchordoid meningiomas.
- Comparison of qualitative MR imaging features and quantitative ADC values, including diffusion-weighted imaging (DWI).
Main Results:
- Meningiomas with chordoid histology showed significantly higher median ADC and normalized ADC values than nonchordoid meningiomas.
- Higher ADC values were also observed in chordoid meningiomas compared to those with focal chordoid histology.
- Diffusion-weighted imaging (DWI) signal intensity was the only qualitative feature significantly associated with chordoid histology.
Conclusions:
- Elevated ADC values can help discriminate chordoid meningiomas from nonchordoid subtypes.
- DWI may aid in the preoperative identification of chordoid meningiomas, while other qualitative MR features are less reliable.
More Related Videos
05:22Author Spotlight: Enhanced Multiplex Immunofluorescent Microscopy Protocol for Neuroscience Research
Published on: June 21, 2024
11:06Subretinal Implantation of RPE on a Carrier in Minipigs: Guidelines for Preoperative Preparations, Surgical Techniques, and Postoperative Care
Published on: November 11, 2022
Related Concept Videos
01:31Adrenergic Receptors: ɑ Subtype
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
01:26Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
01:26Stomach Histology
01:27Liver Histology
Hepatocytes perform a variety of essential functions. They secrete...
01:26Histology of the Large Intestine
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
01:27Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...