Related Experiment Video

Updated: Jan 28, 2026

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
07:19

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids

Published on: January 6, 2023

5.3K

Regorafenib in patients with recurrent high-grade astrocytoma

Sied Kebir1,2,3,4, Laurel Rauschenbach3,4,5, Alexander Radbruch6

  • 1Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.

Journal of Cancer Research and Clinical Oncology
|March 2, 2019
PubMed
Abstract

Insights

Regorafenib showed poor efficacy in recurrent high-grade astrocytoma, with no objective responses and significant adverse events. The drug did not promote infiltrative tumor growth in this small patient group.

Area of Science:

  • Neuro-oncology
  • Cancer therapy
  • Clinical research

Background:

  • Antiangiogenic therapies have not improved outcomes for high-grade astrocytoma.
  • Resistance may involve alternative pro-angiogenic pathways.
  • Regorafenib is a multikinase inhibitor with potential to target these pathways.

Purpose of the Study:

  • To investigate the efficacy and radiographic tumor growth patterns of regorafenib in recurrent high-grade astrocytoma.
  • To assess progression-free survival (PFS), overall survival, and adverse events.
  • To analyze radiographic tumor growth patterns before and after treatment.

Main Methods:

  • Retrospective study of 6 patients with high-grade astrocytoma treated with regorafenib for at least 4 weeks.
  • Efficacy assessed by PFS, overall survival, and Common Toxicity Criteria (CTC) for adverse events.
  • Radiographic tumor growth patterns evaluated at baseline and recurrence.

Main Results:

  • Median PFS was 3.5 months (range 2.0-4.0 months) across 6 patients.
  • All patients had progressive disease, resulting in a 0% objective response rate.
  • CTC grade 3 adverse events occurred in 5 out of 6 patients; local tumor growth was the predominant pattern.

Conclusions:

  • Regorafenib demonstrated very poor performance in recurrent high-grade astrocytoma.
  • High rates of grade 3 adverse events were observed.
  • Regorafenib did not appear to promote infiltrative tumor growth.
Keywords:
AstrocytomaGlioblastomaHigh-grade gliomaRegorafenib

More Related Videos

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry12:25

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

15.9K
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.8K

Related Concept Videos

Graded Potential01:19

Graded Potential

Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.0K
Types of Aggregate Grading01:15

Types of Aggregate Grading

Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.4K
Sieve Analysis and Grading Curves01:19

Sieve Analysis and Grading Curves

Sieve analysis is a method used to determine the particle size distribution of aggregate materials. This process involves the following steps:
971
Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
254
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
232