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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

272
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
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Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

314
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Related Experiment Video

Updated: Jan 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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His Bundle Pacing in Heart Failure-Concept and Current Data.

Philip L Mar1, Subodh R Devabhaktuni1, Gopi Dandamudi2,3

  • 1Indiana University, Indianapolis, IN, USA.

Current Heart Failure Reports
|March 2, 2019
PubMed
Summary
This summary is machine-generated.

His bundle pacing (HBP) offers an alternative to traditional pacing for heart failure. Research indicates HBP can improve cardiac function and reduce symptoms in select patients.

Keywords:
Cardiac dyssynchronyCardiac resynchronization therapyHeart failureHis bundle pacingPacing-induced cardiomyopathy

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • His bundle pacing (HBP) is an emerging alternative to right ventricular pacing (RVP) and cardiac resynchronization therapy.
  • Significant research has focused on HBP for treating congestive heart failure (CHF).

Purpose of the Study:

  • To review the current literature on the use of HBP in treating congestive heart failure (CHF).
  • To provide a comprehensive overview of recent findings and the potential of HBP in cardiac care.

Main Methods:

  • Review of published research on His bundle pacing for congestive heart failure.
  • Analysis of studies evaluating HBP in non-responders to biventricular pacing (BiVP) and other specific patient groups.

Main Results:

  • HBP is beneficial for CHF patients unresponsive to BiVP or with prior lead placement issues.
  • It is also indicated for patients with pacing-induced cardiomyopathy or high RVP burden (>20%).
  • Limited studies show HBP improves cardiac function and reduces heart failure symptoms by utilizing the native His Purkinje system.

Conclusions:

  • HBP presents a viable option for specific heart failure patient populations.
  • Further large-scale randomized trials and technological advancements are needed for widespread clinical adoption and long-term sustainability.