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Published on: March 8, 2019
Synthesis of Urea Derivatives from CO2 and Silylamines
Maotong Xu1, Andrew R Jupp1, Maegan S E Ong1
1Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, M5S3H6, Canada.
Abstract:
A series of thirty-three N,N'-diaryl, dialkyl, and alkyl-aryl ureas have been prepared in pyridine or toluene by reaction of silylamines with CO2 . This protocol is shown to provide facile access to 13 C-labeled ureas, as well as chiral and macrocyclic ureas. These reactions proceed through initial generation of the corresponding silylcarbamates, which subsequently react with silylamine under thermal conditions to afford the thermodynamically favored urea and disilyl ether.
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