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Updated: Jan 28, 2026
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Author Spotlight: A Procedure for Mouse Dorsal Root Ganglion Cryosectioning
Published on: June 9, 2023
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A Prospective Study of Dorsal Root Ganglion Stimulation for Non-Operated Discogenic Low Back Pain
Jan Willem Kallewaard1, Caro Edelbroek1, Michel Terheggen1
1Department of Anesthesiology and Pain Medicine, Rijnstate Hospital Arnhem, Velp, The Netherlands.
Summary
Dorsal root ganglion (DRG) stimulation significantly reduced pain and disability in patients with discogenic low back pain (LBP). This innovative treatment improved quality of life for individuals with chronic LBP without prior surgery.
Area of Science:
- Neuromodulation
- Pain Management
- Spinal Surgery
Background:
- Discogenic low back pain (LBP) significantly impacts physical function and quality of life.
- Spinal cord stimulation (SCS) is effective for neuropathic pain.
- New SCS innovations show promise for chronic LBP, including discogenic pain.
Purpose of the Study:
- To evaluate the efficacy of dorsal root ganglion (DRG) stimulation.
- To assess DRG stimulation in a select group of patients with discogenic LBP.
- To investigate outcomes in patients with no prior history of back surgery.
Main Methods:
- Prospective study design.
- Twenty subjects with confirmed discogenic LBP and no prior surgery.
- DRG stimulation trials followed by permanent implantation for successful candidates.
- Assessment of pain, disability, quality of life, and mood at baseline and 12 months.
Main Results:
- Significant reduction in LBP ratings by 68.3% at 12 months (p < 0.001).
- Oswestry Disability Index scores decreased significantly (p < 0.001) at 6 and 12 months.
- Quality of life (EQ-5D index) improved from 0.61 to 0.84 at 12 months.
Conclusions:
- DRG stimulation effectively improved pain, function, and quality of life in discogenic LBP.
- Further research is needed to establish DRG stimulation's role in chronic discogenic LBP treatment algorithms.
- DRG stimulation represents a potential advancement in managing refractory discogenic LBP.
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