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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
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Studying Normal Tissue Radiation Effects using Extracellular Matrix Hydrogels
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Saving normal tissues - a goal for the ages.

Angela M Groves1, Jacqueline P Williams2,3

  • 1a Department of Pediatrics and Neonatology , University of Rochester Medical Center , Rochester , NY , USA.

International Journal of Radiation Biology
|March 2, 2019
PubMed
Summary
This summary is machine-generated.

For over a century, radiation research has focused on acute effects, neglecting long-term normal tissue damage. New approaches are needed to develop effective radiation countermeasures for better patient outcomes and accidental exposures.

Keywords:
Normal tissue countermeasuresradiation mitigationradiation protection

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Area of Science:

  • Radiation Biology
  • Radioprotection
  • Tissue Injury

Background:

  • Research into preventing or mitigating radiation injury to normal tissues has been ongoing for over a century.
  • Despite extensive efforts, significant breakthroughs in radiation countermeasures remain limited.

Observation:

  • A review of publications in the International Journal of Radiation Biology from 1959-1963, 1987-1991, and 2013-2018 was conducted.
  • The majority of studies focused on agents targeting acute effects of radiation exposure.

Findings:

  • Most research on normal tissue countermeasures has concentrated on immediate post-exposure effects.
  • There has been a limited focus on agents addressing the progressive, long-term complexities of radiation-induced microenvironmental damage.

Implications:

  • A broader research strategy is necessary to develop effective countermeasures for both clinical applications and accidental radiation exposures.
  • Advancements in analytical tools necessitate exploring novel approaches to mitigate long-term normal tissue damage.