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Updated: Jan 28, 2026

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

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The Impact of Narrow Band Imaging in the Detection and Resection of Bladder Tumor in Transitional Cell Carcinoma of

Partho Mukherjee1, Arun Jacob Philip George1, Bijesh Kumar Yadav2

  • 1Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India.

Urology
|March 2, 2019
PubMed
Abstract

Insights

Narrow Band Imaging (NBI) significantly improves bladder cancer tumor detection compared to white light (WL), leading to more complete resections. However, initial tumor resection under NBI presents visibility challenges, particularly for high-risk cases.

Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Bladder cancer diagnosis and treatment rely on effective visualization of tumors.
  • Transurethral resection of bladder tumors (TURBT) is a standard procedure.
  • Limitations in visualizing all tumorous tissue can lead to incomplete resection and recurrence.

Purpose of the Study:

  • To evaluate the impact of Narrow Band Imaging (NBI) on detecting and resecting bladder tumors during TURBT.
  • To compare the efficacy of NBI versus traditional white light (WL) in identifying additional tumorous lesions.
  • To assess the feasibility of performing initial tumor resection using NBI.

Main Methods:

  • A single-center, randomized prospective interventional study.
  • 110 patients with bladder tumors were divided into two arms: WL followed by NBI (Arm A) or NBI followed by WL (Arm B).
  • The number of additional lesions detected by the second light source was analyzed, alongside the feasibility of initial NBI resection.

Main Results:

  • Additional lesions were detected in 37% of patients in Arm A (WL first) versus 9% in Arm B (NBI first), a statistically significant difference (P < .001).
  • Protocol breaches occurred in 7 patients in Arm B, all with high-risk tumors (P < .002).
  • NBI demonstrated superior detection capabilities for bladder tumors.

Conclusions:

  • Narrow Band Imaging (NBI) is superior to white light (WL) for detecting bladder tumors, facilitating more complete tumor resection.
  • Initial resection under NBI poses visibility challenges, especially for high-risk bladder tumors.

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