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Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews
Corinne Blanchet1,2,3, Sébastien Guillaume4,5,6, Flora Bat-Pitault7,8,9
1Maison de Solenn-Maison des Adolescents, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France. corinne.blanchet@aphp.fr.
Journal of Clinical Medicine
|March 3, 2019
Summary
Current anorexia nervosa treatments show limited efficacy. No psychotropic medications aid weight gain, and evidence for symptom relief is weak, necessitating novel therapeutic strategies for nutritional and somatic complications.
Area of Science:
- Psychiatry
- Pharmacology
- Internal Medicine
Background:
- Anorexia nervosa treatment involves nutritional, somatic, and psychiatric interventions.
- Medication use in anorexia nervosa lacks a comprehensive systematic overview.
Purpose of the Study:
- To provide clinicians with an evidence-based overview of medications used for anorexia nervosa since the 1960s.
- To draw practical conclusions for clinical practice and future research.
Main Methods:
- Searches conducted on MEDLINE, Epistemonikos, and Web of Science databases.
- Considered papers published between September 2011 and January 2019.
- Prioritized meta-analyses, systematic reviews, and randomized or open-label trials for evidence-based data.
Main Results:
- Evidence-based data on medication efficacy in anorexia nervosa is scarce.
- No psychotropic medication demonstrated efficacy in promoting weight gain.
- Limited evidence suggests psychotropic drugs may alleviate some psychiatric symptoms.
- No specific approved medication exists for nutritional and somatic complications, highlighting the need for innovative strategies.
Conclusions:
- Current psychotropic medications offer limited benefits for anorexia nervosa, particularly regarding weight gain.
- Addressing multi-organic comorbidities requires exploring innovative therapeutic strategies.
- Further research is needed to develop effective pharmacological treatments for anorexia nervosa.
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