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Allergen Sensitization and Asthma Outcomes among World Trade Center Rescue and Recovery Workers
Belen Rojano1, Erin West2, Emily Ferdermann3
1Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. belen.rojanobroz@mountsinai.org.
Summary
Indoor allergen sensitization did not worsen asthma in World Trade Center (WTC) workers. However, sensitization to Aspergillus Fumigatus, cat, and mouse allergens was linked to decreased asthma morbidity in this WTC-exposed cohort.
Area of Science:
- Environmental Health
- Occupational Health
- Immunology
Background:
- World Trade Center (WTC) rescue and recovery workers frequently experience asthma.
- Comorbidities are linked to poor asthma control, but the role of allergen sensitization remains unclear.
Purpose of the Study:
- To investigate the association between indoor allergen sensitization and increased asthma morbidity in WTC-exposed workers.
Main Methods:
- A prospective cohort of 331 WTC workers with asthma was analyzed.
- Indoor allergen sensitization was measured via serum immunoglobulin E (IgE) levels.
- Validated tools assessed indoor allergen exposure and asthma morbidity (control, quality of life, resource utilization).
Main Results:
- Sensitization prevalence: cat (33%), dog (21%), mouse (17%), dust mite (40%), cockroach (17%), mold (17%).
- No significant association found between most allergen sensitizations and increased asthma morbidity.
- Sensitization to Aspergillus Fumigatus, cat, and mouse allergens was associated with decreased asthma morbidity.
Conclusions:
- Indoor allergen sensitization is common in WTC-exposed asthmatic workers.
- Sensitization does not appear to be a risk factor for increased asthma morbidity in this population.
- Specific allergen sensitizations may be linked to reduced asthma morbidity.
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