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[Interstitial pneumonia in children with acute lymphoblastic leukemia. prophylaxis with pentamidine during induction
Der Radiologe
|June 1, 1978
Insights
Pentamidine prophylaxis significantly reduced interstitial pneumonia (IP) in children undergoing acute lymphoblastic leukemia chemotherapy. This preventative measure lowered IP incidence and severity, improving patient outcomes.
Area of Science:
- Pediatric Oncology
- Pulmonology
- Infectious Disease Prevention
Abstract:
The influence of pentamidine prophylaxis on incidence and degree of interstitial pneumonia (IP) during a standardized induction chemotherapy in 100 children with acute lymphoblastic leukemia has been investigated. For radiologic evaluation we established three stages of IP. With pentamidine prophylaxis the incidence of IP was reduced from 48% to 9%. In addition, there was a significant reduction of severe or lethal courses.