Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.2K
Stem Cell Niche01:26

Stem Cell Niche

6.3K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.3K
Ecological Niches02:02

Ecological Niches

26.4K
All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
26.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.2K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.2K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.2K
Plant Cells and Tissues02:01

Plant Cells and Tissues

65.6K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficacy of double and triple arthrodesis in adult-acquired flatfoot deformity: a retrospective analysis.

BMC surgery·2026
Same author

High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A Hydrogel Delivery System Based on Selenium Nanoparticles and bFGF for Promoting the Repair of Skin Wounds.

Biomedicines·2026
Same author

Sex and social group altered the gut microbiome and fecal metabolome in the critically endangered Yangtze finless porpoise (<i>Neophocaena asiaeorientalis asiaeorientalis</i>).

Current zoology·2026
Same author

IGF2BP1-Mediated m6A Modification Stabilizes HMGA2 mRNA to Promote Intrahepatic Cholangiocarcinoma Progression.

Cellular and molecular gastroenterology and hepatology·2026
Same author

AnyMetric: Universal Metric Optimization for Medical Image Segmentation With Preference Learning.

IEEE journal of biomedical and health informatics·2026
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.5K

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Madelene W Dahlgren1, Stephen W Jones1, Kelly M Cautivo1

  • 1Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Immunity
|March 3, 2019
PubMed
Summary
This summary is machine-generated.

Adventitial stromal cells (ASCs) create niches in tissues that support group 2 innate lymphoid cells (ILC2s), crucial for type 2 immunity. These cells regulate ILC2 expansion and function, impacting allergic responses and tissue repair.

Keywords:
3D-imagingIL-33ILC2sTSLPTh2 cellsallergic asthmagroup 2 innate lymphoid cellsmesenchymal cellsresident lymphocytesstromal cellstissue nichestype 2 immunity

More Related Videos

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

5.6K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.5K

Related Experiment Videos

Last Updated: Jan 28, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.5K
Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

5.6K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

6.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Tissue Engineering

Background:

  • Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity, involved in both physiological tissue remodeling and allergic diseases.
  • The precise tissue locations and cellular interactions of ILC2s remain incompletely understood.

Purpose of the Study:

  • To define the physical tissue niches of ILC2s using quantitative imaging.
  • To identify the cellular components and microenvironmental factors regulating ILC2s.

Main Methods:

  • Quantitative imaging techniques were employed to visualize and analyze ILC2 localization within various tissues.
  • In vitro co-culture systems were used to assess the functional interactions between ILC2s and adventitial stromal cells (ASCs).
  • Experimental helminth infection models were utilized to study ILC2 and ASC dynamics in vivo.

Main Results:

  • A predominant adventitial niche for ILC2s was identified around lung bronchi and larger vessels across multiple tissues.
  • ILC2s were found to closely associate with ASCs, a mesenchymal fibroblast subset expressing IL-33 and TSLP.
  • ASCs produced TSLP, promoting ILC2 accumulation and activation in vitro.
  • Reciprocal signaling between ILC2s/IL-13 and ASCs was observed, leading to ASC expansion and IL-33 production.
  • Depletion of ASCs in vivo impaired lung ILC2 and Th2 cell responses during helminth infection, highlighting the role of ASC-derived IL-33.

Conclusions:

  • Adventitial niches serve as conserved sites where ASCs critically regulate the expansion and function of type 2 lymphocytes.
  • ASCs are essential regulators of type 2 immunity, influencing both ILC2 and Th2 cell responses.
  • Understanding these ASC-ILC2 interactions provides insights into allergic pathology and tissue repair mechanisms.