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c-Jun expression after cerebral hyperstimulation differs between rats and marmosets.

Vanessa Novaes Barros1, Elisa Maria Novaes Barros1, Clivandir da Silva1

  • 1Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil.

Journal of Neuroscience Research
|March 3, 2019
PubMed
Summary

Immediate early genes (IEGs) like c-Fos and c-Jun show distinct expression patterns in rats versus marmosets following stimulation. This differential response impacts how primate and rodent nervous systems adapt to stimuli.

Keywords:
brain plasticityc-Fosc-Jungene expressionimmediate early genesmarmosetsneuronal activation

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Comparative Physiology

Background:

  • Immediate early genes (IEGs) are crucial for cellular adaptation to stimuli.
  • Previous studies indicated differing c-Fos expression between rodents and primates.
  • c-Jun is a key protein that partners with c-Fos in regulating gene expression.

Purpose of the Study:

  • To investigate the expression profile of c-Jun in rats and marmosets under stimulation.
  • To compare c-Jun expression with previously reported c-Fos expression.
  • To understand the differential temporal dynamics of c-Fos and c-Jun in rodents versus primates.

Main Methods:

  • Immunohistochemical analysis of c-Jun expression.
  • Stimulation using pentylenetetrazol (PTZ).
  • Analysis across multiple brain regions (cingulate gyrus, motor cortex, piriform cortex, inferior temporal cortex, visual cortex) in rats and marmosets (Callithrix jacchus).

Main Results:

  • c-Jun expression was more intense but shorter-lasting in marmosets compared to rats.
  • In rats, c-Fos and c-Jun expression profiles were complementary.
  • In marmosets, c-Fos and c-Jun expression peaked concurrently, showing a superimposed pattern.

Conclusions:

  • The distinct temporal expression patterns of c-Fos and c-Jun in primates and rodents suggest species-specific mechanisms for neural adaptation.
  • Fos-Jun dimerization's role in late gene expression may be modulated differently across species.
  • These findings highlight significant differences in nervous system response and adaptation to stimulation between rodents and primates.