An automated home-cage-based 5-choice serial reaction time task for rapid assessment of attention and impulsivity in

B Bruinsma1, H Terra1, S F de Kloet1

  • 1Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.

Psychopharmacology
|March 4, 2019
PubMed
Abstract

Related Concept Videos

Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
63.7K
Acids, Bases and Neutralization Reactions01:27

Acids, Bases and Neutralization Reactions

Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...
9.6K
Impulse01:13

Impulse

According to Newton’s second law of motion, the rate of change of the momentum of an object is the net external force acting on it. The total change in momentum between two timepoints thus depends on both the external force acting on it and the time over which it acts. Describing this mathematically, the total change of an object’s motion is proportional to the force vector and the time over which it is applied. This product is called impulse.
Additionally, it can be shown that the...
21.7K
Impulse Response01:17

Impulse Response

The impulse response is the system's reaction to an input impulse. In an RC circuit, the voltage source is the input, and the capacitor's voltage is the output. The system's state and output response before and after input excitation are distinctly defined.
Kirchhoff's law forms an input signal equation, with the capacitor's current and voltage providing the output. Substituting the current and dividing by RC yields a differential equation. The output for an impulse input is the impulse...
743
Factors Affecting α-Alkylation of Ketones: Choice of Base01:10

Factors Affecting α-Alkylation of Ketones: Choice of Base

α-Alkylation of ketones is achieved in the presence of alkyl halides and a base. The reaction proceeds via the formation of an enolate ion followed by nucleophilic substitution. The choice of base employed is essential as it is the key factor in determining the reaction outcome.
The reaction involving bases like EtO− whose conjugate acid EtOH (pKa = 15.9) is stronger than the ketone (pKa = 19.2) results in an equilibrium mixture with higher ketone concentration. As a consequence,...
3.6K
Serial Position Effect01:03

Serial Position Effect

The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
539