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Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
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Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray-drying processing
Emma Loughrill1, Sharon Thompson1, Samuel Owusu-Ware1
1Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
Food Chemistry
|March 5, 2019
Summary
Direct spray drying effectively encapsulates docosahexaenoic acid (DHA) using HPMCAS, yielding higher DHA quantities and improved stability compared to spray-dried solid lipid nanoparticles for infant nutrition.
Area of Science:
- Food Science and Technology
- Nutritional Biochemistry
- Materials Science
Background:
- Docosahexaenoic acid (DHA), an omega-3 fatty acid, is crucial for infant visual and brain development.
- Effective encapsulation is needed to stabilize DHA and control its release in food matrices.
- Hydroxyl-propyl-methyl-cellulose-acetate-succinate (HPMCAS) is a pH-dependent polymer suitable for encapsulation.
Purpose of the Study:
- To explore two distinct methods for microencapsulating DHA using HPMCAS.
- To compare the efficiency, stability, and release characteristics of DHA encapsulated via different approaches.
Main Methods:
- Direct Spray Drying (DSD) of DHA/HPMCAS organic solutions.
- Production of DHA solid lipid nanoparticles (SLNs) via high-pressure homogenization, followed by spray drying in HPMCAS aqueous solutions.
Main Results:
- DSD achieved significantly higher DHA encapsulation (2.09 µg/100 µg) compared to spray-dried SLNs (0.60 µg/100 µg).
- The DSD method demonstrated enhanced DHA stability.
- DHA released from DSD samples showed a 2-hour lag time in acidic media, followed by rapid release at pH 6.8.
Conclusions:
- Direct spray drying is a superior method for microencapsulating DHA with HPMCAS, offering higher yields and better stability.
- The encapsulation method influences DHA release kinetics, with potential applications in controlled delivery systems for infant nutrition.
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