Related Experiment Videos
Hyperinsulinuria in diabetic ketoacidosis.
The International Journal of Pediatric Nephrology
|January 1, 1986
Summary
Diabetic children show higher urinary insulin excretion than healthy peers. This hyperinsulinuria, especially during ketoacidosis, indicates reversible kidney dysfunction and may contribute to diabetic nephropathy.
Area of Science:
- Pediatric Endocrinology
- Nephrology
Background:
- Urinary insulin excretion is a marker of insulin metabolism.
- Diabetic ketoacidosis is a serious complication in children with diabetes.
Purpose of the Study:
- To investigate urinary insulin excretion in diabetic children.
- To assess the reversibility of urinary insulin excretion changes after ketoacidosis.
Main Methods:
- Measurement of urinary insulin excretion in well-controlled diabetic children, ketoacidotic diabetic children, and healthy controls.
- Re-measurement of urinary insulin excretion after recovery from diabetic ketoacidosis.
Main Results:
- Well-controlled diabetics exhibited significantly higher urinary insulin excretion than healthy controls.
- Ketoacidotic diabetic children showed a 50-fold increase in urinary insulin excretion.
- Hyperinsulinuria was reversible, with excretion rates decreasing significantly after recovery from coma.
Conclusions:
- Hyperinsulinuria in diabetic ketoacidosis suggests severe, reversible tubular dysfunction.
- Recurrent episodes of ketoacidosis may be implicated in the pathogenesis of diabetic nephropathy.