Related Experiment Video
Updated: Jan 28, 2026
Live Imaging of Mouse Secondary Palate Fusion
Published on: July 27, 2017
Cellular and molecular mechanisms of cleft palate development
Anita S Deshpande1, Steven L Goudy1
1From the Department of Otolaryngology-Head and Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A.
Abstract:
Cleft lip and palate are common craniofacial deformities. The etiology underlying these deformities is complex and multifactorial and they can occur as part of one of many chromosomal syndromes, Mendelian single gene disorders, teratogenic effects, and as yet uncharacterized syndromes. Our paper will provide an overview of the multiple genes and molecular pathways that have been implicated in palatal fusion. We believe that understanding the molecular mechanisms of cleft formation can help clinicians anticipate which patients may have difficulties healing and in the future allow them to make surgical and medical treatment decisions based on genetic information.
Related Concept Videos
03:06Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
02:00Molecular Models
03:51Molecular Orbital Theory II
02:54Molecular and Ionic Solids
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
02:35Molecular Orbital Theory I
02:27Predicting Molecular Geometry