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Updated: Jan 28, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
Suppression of scratching-induced pleasurable sensation by compression nerve blocking and its association with itch
Hideki Mochizuki1,2, Alina Shevchenko1, Leigh A Nattkemper2
1Department of Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Abstract:
Itch can be suppressed by scratching. At the same time, scratching evokes a pleasurable sensation. In the present study, we investigated the peripheral mechanism of scratching-induced pleasurability and its association with itch relief using compression nerve block. We found that myelinated nerve fibers (Aβ-fibers and possibly Aδ-fibers), are involved in transmission of scratching-induced pleasurability. We observed that itch relief effect was the same regardless of whether the pleasurable sensation was evoked by scratching an itch, indicating that pleasure is not a necessary component to induce itch relief. This is the first study to investigate the peripheral mechanism of scratching-induced pleasurability and itch relief.
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