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Updated: Jan 28, 2026
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Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
Published on: July 7, 2023
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[Pain and fatigue - a systematic review].
Rupert Conrad1, Franziska Geiser1, Martin Mücke2,3,4
1Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie Universitätsklinikum Bonn Sigmund-Freud-Str. 25 53127 Bonn Deutschland Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie.
Summary
Chronic pain and fatigue often coexist and require integrated treatment approaches. Understanding their connection to centralized pain syndrome offers new therapeutic strategies.
Area of Science:
- Medical Science
- Neuroscience
- Symptomology
Background:
- Chronic pain and fatigue frequently co-occur, presenting a complex clinical picture across various diseases.
- Current medical practice has largely overlooked integrative explanatory models for these interconnected symptoms.
Purpose of the Study:
- To systematically review high-quality intervention studies focusing on the simultaneous treatment of pain and fatigue.
- To explore current explanatory models for the co-occurrence of pain and fatigue.
Main Methods:
- Systematic literature search across Embase, Medline, PsychInfo, and CENTRAL databases.
- Inclusion of 158 high-quality intervention studies from 1,496 initial hits.
- Analysis of studies related to tumor catabolism, fibromyalgia, chronic fatigue, rheumatoid arthritis, and osteoarthritis.
Main Results:
- The review identified key clinical conditions where pain and fatigue commonly manifest.
- Current explanations highlight the role of proinflammatory microglia activation in centralized pain syndrome.
- Fatigue is proposed as a protective, evolutionary response within this model.
Conclusions:
- A comprehensive understanding of the link between centralized pain syndrome and fatigue is crucial.
- This understanding can pave the way for novel explanatory frameworks and treatment interventions.
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