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Updated: Jan 28, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Is Cannabis Harmless? Focus on Brain Function.

John C Ashton1

  • 1Department of Pharmacology & Toxicology, Otago School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Current Drug Research Reviews
|March 5, 2019
PubMed
Summary
This summary is machine-generated.

Heavy cannabis use, especially starting in adolescence, can lead to long-term mental and life functioning impairments. Cessation may involve withdrawal and residual cognitive deficits lasting weeks.

Keywords:
Cannabisadolescencecessationharmlife outcomesmodel.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Public Health

Background:

  • The long-term mental health effects of cannabis use are debated.
  • Understanding residual and persistent cognitive deficits is crucial.

Purpose of the Study:

  • To evaluate evidence on long-term cannabis use impacts on mental functioning.
  • To assess risks associated with early-onset heavy cannabis consumption.

Main Methods:

  • Systematic review of human studies.
  • Analysis of detrimental effects on cognitive and life functioning.

Main Results:

  • Heavy cannabis use causes immediate cognitive deficits and withdrawal symptoms.
  • Adolescent-onset heavy use is linked to lifelong impairments and increased schizophrenia risk.
  • Associated with socioeconomic decline and mental health issues.

Conclusions:

  • Adolescent-onset heavy cannabis use significantly increases the risk of long-term mental and life functioning impairment.
  • Early intervention and awareness are critical for mitigating risks.