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Updated: Jan 28, 2026

Multimodality Diagnosis of Mesenteric Ischemia

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

Sclerosing Mesenteritis.

Christopher J Danford¹, Steven C Lin¹, Jacqueline L Wolf¹

¹Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

The American Journal of Gastroenterology

|March 5, 2019

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Sclerosing mesenteritis, a rare condition causing mesenteric fibrosis, is often benign but can cause complications. Treatment involves corticosteroids and tamoxifen, with surgery reserved for severe cases.

Area of Science:

Gastroenterology
Pathology
Radiology

Background:

Sclerosing mesenteritis is a rare, non-neoplastic disorder of the small bowel mesentery.
Pathogenesis is poorly understood, with potential links to surgery, trauma, autoimmunity, infection, ischemia, and malignancy.
Limited understanding is compounded by rarity and inconsistent terminology.

Purpose of the Study:

To review the current understanding of sclerosing mesenteritis.
To discuss its clinical presentation, diagnosis, and management.
To emphasize the importance of clear communication among specialists.

Main Methods:

Literature review of sclerosing mesenteritis.
Analysis of clinical course and diagnostic findings.

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Evaluation of treatment strategies based on case series and fibrosing disorder experience.

Main Results:

Sclerosing mesenteritis is often incidentally diagnosed on imaging.
Symptoms can arise from mass effect, leading to bowel obstruction, chylous ascites, or mesenteric ischemia.
First-line treatment for symptomatic patients includes corticosteroids and tamoxifen.

Conclusions:

Sclerosing mesenteritis typically follows a benign course but can be symptomatic.
Surgical intervention may be necessary for refractory cases but complete resection is challenging.
Standardized terminology and interdisciplinary communication are crucial for advancing the understanding and care of this condition.