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Related Experiment Video

Updated: Jan 28, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both?

Marco Ranucci¹, Umberto Di Dedda¹, Ekaterina Baryshnikova¹

¹Department Of Cardiovascular Anaesthesia and Intensive Care Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

|March 5, 2019

Summary

This summary is machine-generated.

The elasticity difference in rotational thromboelastometry (ROTEM) better reflects platelet function and count than the amplitude difference. This suggests using elasticity difference (PCSel) over amplitude difference (PCSamp) for clinical assessment.

Keywords:

Cardiac platelet function tests surgery thromboelastometry

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Area of Science:

Cardiovascular Medicine
Hematology
Medical Technology

Background:

Rotational thromboelastometry (ROTEM) assesses blood coagulation.
Platelet contribution to clot strength (PCS) is typically measured by amplitude difference (PCSamp).
Elasticity difference (PCSel) is an underutilized metric for PCS.

Purpose of the Study:

To evaluate PCSamp and PCSel's ability to reflect platelet count and function.
To compare PCSamp and PCSel in patients undergoing cardiac surgery.

Main Methods:

ROTEM analysis (EXTEM and FIBTEM) and platelet function tests (ADPtest, TRAPtest) were performed on 103 cardiac surgery patients.
Associations between PCSamp, PCSel, platelet count, and function were analyzed.
Multivariable modeling and discrimination analysis were used.

Main Results:

PCSel showed a stronger association with platelet count and ADPtest-measured function (R coefficient 0.55-0.71) compared to PCSamp (R coefficient 0.32-0.39).
No association was found between PCS metrics and TRAPtest.
PCSel demonstrated excellent discrimination for predicting low platelet count/function (c-statistic 0.837).

Conclusions:

PCSel is a more reliable indicator of platelet count and function than PCSamp.
The study recommends using PCSel over PCSamp in clinical practice for assessing platelet contribution to clot strength.