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Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation
Yiyin Chen1, Sally Liu2, Sean X Leng2
1Division of Geriatrics, Xiangya Second Hospital of Central South University, Changsha, Hunan Province, China.
Clinical Therapeutics
|March 6, 2019
Summary
Chronic low-grade inflammatory phenotype (CLIP) is linked to aging and frailty. Interventions like diet and exercise show promise for managing CLIP and improving health outcomes.
Area of Science:
- Gerontology and immunology
- Pathophysiology of chronic diseases
Background:
- Chronic low-grade inflammatory phenotype (CLIP) is a systemic inflammatory state associated with aging (inflammaging) and immunosenescence.
- CLIP is characterized by elevated serum inflammatory mediators like IL-6 and CRP, involving complex cellular and molecular pathways.
Purpose of the Study:
- To provide an overview of the chronic low-grade inflammatory phenotype (CLIP).
- To examine CLIP's role in the pathogenesis of frailty and other chronic conditions.
- To identify potential causative factors and interventions for CLIP.
Main Methods:
- Review of published clinical and laboratory studies.
- Summarization of expert opinions from published reviews.
Main Results:
- CLIP is a significant contributor to frailty and numerous chronic conditions.
- Potential causative factors include viral infections, cellular senescence, gut dysbiosis, and obesity.
- Non-pharmacologic interventions (caloric restriction, exercise) and agents like metformin and resveratrol show therapeutic potential.
Conclusions:
- CLIP is a crucial pathophysiologic process in frailty and chronic diseases.
- Understanding CLIP offers opportunities for novel prevention and therapeutic strategies.
- Targeting CLIP may lead to improved health outcomes in aging populations.
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