Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Histone Modification02:32

Histone Modification

4.5K
4.5K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.4K
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

182
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
182
Behavior Modification01:21

Behavior Modification

630
Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
630
Protein Modifications in the RER01:26

Protein Modifications in the RER

7.0K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leucine-Rich Repeat Extension 7 Gene Confers Cotton Resistance to Verticillium Wilt.

International journal of molecular sciences·2026
Same author

Reaction Mechanism of Electrodeposited ε-MnO<sub>2</sub>: A Proton-Centered Pathway in Aqueous Zn-Ion Systems.

ACS applied materials & interfaces·2026
Same author

Statistical White-Line Analysis in High-Throughput TXM-XANES for Chemical State Quantification.

Photon science·2026
Same author

Understanding the Performance Gap between Polycrystalline and Single-Crystal Nickel-Rich Layered Oxide Cathodes.

Journal of the American Chemical Society·2026
Same author

Integrated Transcriptomic and Metabolomic Analysis Reveals GHABF3-Mediated ABA Signaling Governs Enhanced Verticillium Wilt Resistance in Cotton.

Physiologia plantarum·2025
Same author

Operando X-ray imaging reveals size-dependent evolution of cobalt oxide thermochemical material during thermal redox cycles.

Nature communications·2025

Related Experiment Video

Updated: Jan 28, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

12.7K

The mechanism of eutectic modification by trace impurities.

Saman Moniri1, Xianghui Xiao2,3, Ashwin J Shahani4

  • 1Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, United States. moniri@umich.edu.

Scientific Reports
|March 6, 2019
PubMed
Summary

Trace metal impurities significantly alter eutectic crystallization by changing the stacking sequence of the faceted phase. This leads to altered microstructures and topological properties, offering new insights into eutectic modification.

More Related Videos

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry
07:10

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry

Published on: April 29, 2020

2.0K
Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities
11:42

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities

Published on: July 24, 2015

16.1K

Related Experiment Videos

Last Updated: Jan 28, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

12.7K
3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry
07:10

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry

Published on: April 29, 2020

2.0K
Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities
11:42

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities

Published on: July 24, 2015

16.1K

Area of Science:

  • Materials Science
  • Crystallization Science
  • Solidification Science

Background:

  • Understanding the impact of impurities on material properties is crucial for rational material design.
  • Eutectic crystallization is complex, especially with trace metallic impurities (eutectic modification), with origins of microstructural changes poorly understood.
  • Existing theories do not fully explain the observed microstructural changes during eutectic modification.

Purpose of the Study:

  • To investigate the influence of trace metal impurities on the growth of irregular (faceted-non-faceted) eutectics.
  • To elucidate the origins of drastic microstructural changes observed during eutectic modification.
  • To provide a unified picture of eutectic modification through multi-modal characterization.

Main Methods:

  • Integrated imaging approach using dynamic and 3D synchrotron-based X-ray imaging.
  • Ex situ crystallographic characterization of solidified specimens.
  • Development of a quantitative topological framework.

Main Results:

  • Trace metal impurities lead to markedly different microstructural and topological properties of eutectic constituents.
  • Impurities selectively alter the stacking sequence of the faceted phase, inhibiting its steady-state growth.
  • The non-faceted phase advances into the melt, engulfing the faceted phase.

Conclusions:

  • The study provides a unified picture of eutectic modification, revealing impurity-induced changes in stacking sequence and growth dynamics.
  • Experimental observations are rationalized using a quantitative topological framework.
  • Findings offer new insights into controlling eutectic microstructures through impurity manipulation.