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Published on: May 4, 2022
Idarucizumab in High-risk Thoracic Surgery
R López-Vilella1, J Sanz-Sánchez1, I Sánchez-Lázaro1
1Heart Failure and Transplantation Unit, Cardiology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Abstract:
Direct oral anticoagulants have suggested a favorable profile compared with vitamin K antagonists. However, the lack of treatment to reverse the effect of direct oral anticoagulants has limited its use in some patients who require rapid reversal of anticoagulation, as those included in the transplant waiting list. Idarucizumab is a recently approved drug to reverse the anticoagulant effect of dabigatran. However, the clinical experience when using this drug is scarce. Herein, we present a clinical case on anticoagulation reversal with idarucizumab to perform heart and lung transplantation in a patient with Eisenmenger syndrome.
Insights
Direct oral anticoagulants offer benefits but lack reversal agents. Idarucizumab effectively reversed dabigatran
Area of Science:
- Cardiology
- Pharmacology
Background:
- Direct oral anticoagulants (DOACs) present an alternative to vitamin K antagonists.
- Limited reversal options for DOACs pose challenges in urgent clinical scenarios, such as transplantation.
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