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A highly sensitive and versatile chiral sensor based on a top-gate organic field effect transistor functionalized
Xuepeng Wang1, Yong Wang, Yifan Wu
1School of Chemical Engineering and Technology, Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin University, Tianjin 300072, China. xiaoyin@tju.edu.cn.
The Analyst
|March 6, 2019
Summary
This study introduces a chiral organic field effect transistor (COFET) for enantiomer discrimination. The novel device achieves highly sensitive, real-time chiral sensing, even for uncharged molecules.
Area of Science:
- Chemical Sensors
- Materials Science
- Analytical Chemistry
Background:
- Chiral discrimination is challenging for field effect transistors (FETs) as enantiomers have identical charges.
- Existing FET sensors rely on analyte charge, limiting their ability to detect uncharged chiral molecules.
Purpose of the Study:
- To develop a chiral organic field effect transistor (COFET) for sensitive, real-time enantiomer discrimination.
- To overcome the limitations of charge-dependent FET sensors in chiral analysis.
Main Methods:
- Fabrication of a COFET using a self-assembled thiolated β-cyclodextrin (SH-β-CD) monolayer on a gold top-gate electrode.
- Utilizing changes in work function and surface potential for chiral recognition based on isomer-specific complex formation.
Main Results:
- Achieved lowest detection concentration (LDC) of 10-12 M for diverse acidic enantiomers.
- Demonstrated successful chiral sensing independent of analyte charge, including uncharged enantiomers.
- Exhibited composition-dependent responses for enantiomer mixtures, showing potential for quantitative analysis.
Conclusions:
- The developed COFET offers a novel approach for rapid, highly sensitive, and real-time chiral discrimination.
- This technology enables chiral resolution for both charged and uncharged enantiomers.
- The COFET shows promise for quantitative chiral analysis of pharmaceuticals.
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