Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects of d-amphetamine on human aggressive behavior.

D R Cherek, J L Steinberg, T H Kelly

    Psychopharmacology
    |January 1, 1986
    PubMed
    Summary

    D-amphetamine increased aggressive and non-aggressive behaviors in male subjects. Higher doses reduced aggression, while monetary-reinforced responses remained elevated, suggesting dose-dependent effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study.

    Psychiatry research. Neuroimaging·2020
    Same author

    Use of the Fossomatic Somatic Cell Counts in a Mastitis Control Program <sup>1</sup>.

    Journal of food protection·2019
    Same author

    Bone Phenotype Assessed by HRpQCT and Associations with Fracture Risk in the GLOW Study.

    Calcified tissue international·2017
    Same author

    Femoral impaction bone grafting with the Elite Plus stem.

    Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
    Same author

    A review of the methods used to define glucocorticoid exposure and risk attribution when investigating the risk of fracture in a rheumatoid arthritis population.

    Bone·2016
    Same author

    Cluster analysis of bone microarchitecture from high resolution peripheral quantitative computed tomography demonstrates two separate phenotypes associated with high fracture risk in men and women.

    Bone·2016

    Area of Science:

    • Psychopharmacology
    • Behavioral neuroscience
    • Experimental psychology

    Background:

    • Amphetamines are known stimulants with complex effects on human behavior.
    • Understanding the dose-dependent impact of amphetamines on aggression and reward-seeking is crucial.

    Purpose of the Study:

    • To investigate the effects of d-amphetamine on aggressive and non-aggressive (monetary) behaviors in a controlled laboratory setting.
    • To determine if these effects are dose-dependent.

    Main Methods:

    • Male participants received placebo or d-amphetamine (5, 10, 20 mg/70 kg).
    • Behavioral responses were measured using button presses for monetary gain (non-aggressive) or to subtract points from a fictitious partner (aggressive).
    • Aggression was elicited by subtracting points from participants attributed to the fictitious partner.

    Main Results:

    • D-amphetamine generally increased both aggressive and non-aggressive responding, particularly at 5 and 10 mg/70 kg.
    • At the highest dose (20 mg/70 kg), aggressive responding decreased to placebo levels.
    • Monetary-reinforced responding remained elevated even at the highest d-amphetamine dose.

    Conclusions:

    • D-amphetamine exhibits dose-dependent effects on aggression and reward-seeking behavior.
    • Lower doses may enhance both aggressive and instrumental behaviors, while higher doses may selectively suppress aggression.
    • These findings have implications for understanding stimulant effects in behavioral contexts.

    Related Experiment Videos