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Updated: Jan 28, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Urceoloids A and B, Two C19 Steroids with a Rearranged Spirocyclic Carbon Skeleton from Urceola quintaretii
Yu-Hao Ren1,2, Qun-Fang Liu1, Li Chen1,2
1State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
Abstract:
Urceoloids A (1) and B (2), two C19 steroids with a rearranged new carbon skeleton by featuring a very unique spiro[4.4]nona-3,6,8-triene system, and a biosynthetically related known steroid (3) were isolated from Urceola quintaretii. Their structures were completely established by a combined method. A plausible biosynthetic pathway for the new carbon skeleton represented by compounds 1 and 2 was proposed. Compounds 2 and 3 showed immunosuppressive activities.
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