Related Experiment Video
Updated: Jan 28, 2026
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Bowel Preparation for Colonoscopy in Children: 1 Day PEG-3350 with Bisacodyl versus 3 Day Sennosides
Engin Tutar1, Nevzat Aykut Bayrak1, Burcu Volkan1
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Istanbul, Turkey.
Insights
A 1-day bowel preparation (BP) using polyethylene glycol-3350 with bisacodyl (PEG-B) is as effective and safe as a 3-day sennosides regimen for pediatric colonoscopy. The PEG-B regimen offers improved patient comfort and ease of administration.
Area of Science:
- Pediatric Gastroenterology
- Endoscopy Procedures
- Gastrointestinal Pharmacology
Background:
- Bowel preparation (BP) is crucial for pediatric colonoscopy but remains challenging.
- Polyethylene glycol (PEG)-based regimens are increasingly preferred for pediatric BP.
- Comparing novel short-duration regimens with traditional methods is essential.
Purpose of the Study:
- To evaluate the efficacy and safety of a 1-day PEG-3350 with bisacodyl (PEG-B) regimen.
- To compare the 1-day PEG-B regimen against a 3-day sennosides A+B regimen in children.
- To assess patient comfort and compliance with different pediatric BP protocols.
Main Methods:
- A prospective, randomized, single-blinded study involving children aged 2-18 years.
- Participants were assigned to either a 1-day PEG-B group or a 3-day Senna group.
- Efficacy assessed using Boston and Ottawa Bowel Preparation scales; safety evaluated via biochemistry and adverse events.
Main Results:
- Similar successful BP rates between PEG-B (88.3% Boston, 85% Ottawa) and Senna (86% Boston, 84.4% Ottawa) groups.
- High cecal intubation rates achieved in both groups (96.7% PEG-B, 93.8% Senna).
- PEG-B demonstrated superior ease of administration and less disruption to daily activities (p < 0.05), with no significant adverse events or biochemical abnormalities.
Conclusions:
- The 1-day PEG-B regimen is an effective and safe alternative to the 3-day sennosides regimen for pediatric bowel preparation.
- PEG-B offers advantages in terms of shorter duration, easier administration, and enhanced patient comfort.
- Excellent correlation between Boston and Ottawa scales was noted in pediatric patients, validating their utility.
Background And Objectives:
Bowel preparation (BP) for colonoscopy is a challenging procedure in children and different regimens have been used for this purpose. Polyethylene glycol (PEG) is the most preferred agent in recent years. The primary aim of this study was to evaluate the efficacy of 1-day PEG-3350 with bisacodyl (PEG-B) and comparing it with 3-day sennosides A+B.
Method:
In this prospective, randomized, and single-blinded study, children aged 2-18 years were included in the PEG-B group for 1 day or in Senna group for 3 days. The effectiveness of BP was assessed according to the Ottawa and Boston BP scales, compliance and adverse effects were also recorded. Pre- and post-preparation biochemistry were obtained for investigation of safety of both regimens.
Results:
Successful BP was observed in 88.3% (n = 53/60) of PEG-B and 86% (n = 55/64) of Senna groups according to Boston scale, and it was 85% (n = 51/60) and 84.4% (n = 54/64), respectively, according to Ottawa scale. The cecal intubation rate was 96.7% (n = 58/60) in the PEG-B group and 93.8% (n = 60/64) in the Senna group. Ease of administration and disturbance in regular daily activities was better in the PEG-B group (p < 0.05). There was no major adverse event and biochemical abnormality in both groups. The correlation between Ottawa and Boston scales was found to be excellent (r2 = -0.954, p < 0.01).
Conclusions:
The efficacy, safety, and adverse effect profile of 1-day BP with PEG-B regimen was found to be similar to 3-day sennosides regimen, however, the PEG-B regimen had advantages such as short duration, ease of administration, and better patient comfort. Also, high correlation rate between the Boston and Ottawa scales in pediatric patients was remarkable.
Related Concept Videos
01:25Endoscopic Procedures II: Colonoscopy
01:28Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
01:22Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
01:26Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
01:07Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...