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Updated: Jan 28, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Hypertension and Framingham general vascular risk score in retinal vein occlusion]
M Lisa Gracia1, M Vieitez Santiago1, Z Salmón Gonzalez1
1Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Santander, España.
Insights
Arterial hypertension is significantly more common in patients with retinal vein occlusion (RVO) than in controls, with diagnosis often stemming from RVO. Retinal vein occlusion should be viewed as a vascular event.
Area of Science:
- Ophthalmology
- Cardiology
- Vascular Medicine
Background:
- Retinal vein occlusion (RVO) is a significant ocular vascular event.
- Understanding associated systemic vascular risk factors is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of arterial hypertension (AHT), blood pressure levels (systolic and diastolic), and Framingham vascular risk scores (FRS) in patients with RVO compared to a control group.
- To investigate the relationship between RVO and systemic vascular health indicators.
Main Methods:
- A prospective, cross-sectional case-control study.
- Inclusion of patients diagnosed with RVO and a matched control group.
- Analysis of clinical and laboratory variables, including blood pressure and FRS.
Main Results:
- Patients with RVO exhibited a significantly higher prevalence of AHT (71.5% vs. 51.2%) and elevated systolic (148±22 mmHg vs. 138±18 mmHg) and diastolic blood pressure (83±10 mmHg vs. 77±10 mmHg) compared to controls.
- AHT was newly diagnosed in 23.8% of RVO cases.
- The Framingham vascular risk score was significantly higher in the RVO group (11±8.3 vs. 8.25±6.3).
- No significant differences were observed in studied parameters between central and peripheral RVO.
Conclusions:
- Arterial hypertension is highly prevalent and significantly more common in patients with RVO.
- RVO diagnosis frequently leads to the identification and management of hypertension.
- The Framingham vascular risk score is elevated in RVO patients, suggesting RVO should be considered a vascular event for therapeutic goal setting.
Objectives:
To determine the prevalence of arterial hypertension (AHT), systolic blood pressure (SBP), the diastolic blood pressure (DPB), and the Framingham vascular risk score (FRS), in subjects with retinal vein occlusion (RVO), as well as in a control group.
Patients And Method:
A prospective, cross-sectional case and control study was conducted on all patients with a diagnosis of RVO referred to the General Medicine Clinic, and comparing them with a control group. An analysis was performed on the clinical and laboratory variables.
Results:
A total of 253 patients with RVO were studied (132 males and 121 females) and 244 controls (112 males and 132 females) of similar age (67.9±12.3 vs. 68.1±9.2 años). The prevalence of AHT, and the SBP and DPB values in the clinic after the RVO were significantly higher in patients with RVO than in the controls (71.5% vs. 51.2%), SBP mmHg (148±22 vs. 138±18mmHg), DBP mmHg (83±10 vs. 77±10mmHg). The de novo diagnosis of AHT was made from the RVO in 23.8% of the cases. Significant differences were found in the FRS between the patients with RVO and the controls (11±8.3 vs. 8.25±6.3. There were no differences in any of the parameters studied between patients with peripheral or central RVO.
Conclusions:
Hypertension is very prevalent as significantly more common in patients with RVO than in controls. Its diagnosis and treatment is often established from the RVO. The FRS is greater in patients with RVO. There were no differences in any of the parameters studied between patients with peripheral or central RVO. It is suggested that RVO should be considered a vascular event when defining therapeutic objectives.
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