Interrelation of Ca²⁺ and PE_PGRS proteins during Mycobacterium tuberculosis pathogenesis

In today's era tuberculosis is a major threat to human population. The lethality of this disease is caused by very efficiently thrived bacteria Mycobacterium tuberculosis (M. tuberculosis). Ca²⁺ plays crucial role in maintenance of cellular homeostasis. Bacilli survival in human alveolar macrophages majorly depends on disruption in Ca²⁺ signaling. Bacilli sustainability in phagosome lies in the interruption of phagolysosomal fusion, which is possible because of low intracellular Ca²⁺ concentration. Bacilli contain various Ca²⁺ binding proteins which help in regulation of Ca²⁺ signaling for its own benefit. For the survival of pathogen, it requires alteration in normal Ca²⁺ concentration in healthy cell. In this review we aim to find the various Ca²⁺ binding domains which are present in several Ca²⁺ binding proteins of M. tuberculosis and variety of roles played by Ca²⁺ to survive bacilli within host cell. This manuscript emphasizes the Ca²⁺ binding domains present in PE_PGRS group of gene family and their functionality in M. tuberculosis survival and pathogenesis.