Related Experiment Video

Updated: Jan 28, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

829

[Differential expression of lncRNA in patients with coronary artery disease plus clopidogrel resistance]

Wenjian Xie1, Beibei Huang2, Qian Yin2

  • 1Department of Cardiology, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|March 7, 2019
PubMed

Insights

Clopidogrel resistance in coronary artery disease patients is linked to specific long non-coding RNA (lncRNA) changes. Two lncRNAs are upregulated, and one is downregulated in resistant patients, offering potential biomarkers.

Area of Science:

  • Genomics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Clopidogrel is a key antiplatelet medication used after percutaneous coronary intervention (PCI).
  • Clopidogrel resistance can lead to adverse cardiovascular events.

Purpose of the Study:

  • To investigate the differential expression of long non-coding RNAs (lncRNAs) in patients with CAD experiencing clopidogrel resistance.
  • To identify specific lncRNAs associated with clopidogrel resistance.

Main Methods:

  • Patients undergoing PCI and treated with clopidogrel were enrolled.
  • Patients were categorized into clopidogrel-sensitive and clopidogrel-resistant groups based on platelet aggregation.
  • lncRNA expression profiling was performed using microarray and validated with real-time RT-PCR.

Main Results:

  • lncRNA microarray analysis revealed 11 upregulated and 8 downregulated lncRNAs in peripheral leukocytes of clopidogrel-resistant patients.
  • Real-time RT-PCR confirmed the differential expression of three specific lncRNAs: NONHSAT083775.2 and NONHSAT107804.2 were upregulated, while NONHSAT133455.2 was downregulated in the resistant group.

Conclusions:

  • Clopidogrel resistance in CAD patients is associated with distinct lncRNA expression patterns.
  • Upregulation of NONHSAT083775.2 and NONHSAT107804.2, and downregulation of NONHSAT133455.2 in leukocytes may serve as potential indicators of clopidogrel resistance.
Abstract

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.2K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.0K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
415
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
246
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
359