Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.1K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.1K
Dosage Regimen: Multiple Oral Dosage01:25

Dosage Regimen: Multiple Oral Dosage

250
Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
250
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.2K
Dosage Compensation02:50

Dosage Compensation

7.3K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
7.3K
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

178
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
178
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.4K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Knock-In Igfn1<sup>iCre</sup> transgenic mouse line provides partial developmental access to type-7 bipolar cells.

Neuroscience research·2026
Same author

Cytoplasmic competition between separate parental pronuclei in zygotes.

Nature·2026
Same author

Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses.

Nature communications·2026
Same author

Cohesin prevents local mixing of condensed euchromatic domains in living human cells.

bioRxiv : the preprint server for biology·2026
Same author

Importin α characterizes a micronuclear environment associated with genomic instability in human cancer cells.

Journal of cell science·2026
Same author

Dilution-Derived Growth Lag and Photosynthetic Responses in the Oleaginous Diatom Fistulifera solaris.

Marine biotechnology (New York, N.Y.)·2026

Related Experiment Video

Updated: Jan 28, 2026

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

2.1K

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation.

Takashi Kozuka1,2, Yoshihiro Omori1,2, Satoshi Watanabe1,2

  • 1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Scientific Reports
|March 7, 2019
PubMed
Summary

MicroRNA-124 (miR-124) dosage impacts normal brain function. Reduced miR-124 impairs prepulse inhibition and social behavior by altering dopamine receptor D2 (Drd2) signaling in the prefrontal cortex.

More Related Videos

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

844
Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

12.5K

Related Experiment Videos

Last Updated: Jan 28, 2026

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

2.1K
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

844
Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

12.5K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA-124 (miR-124) is abundant in the central nervous system (CNS) and crucial for its development.
  • Its role in normal brain function remains largely unexplored.

Purpose of the Study:

  • To investigate the function of miR-124 in normal brain function using a mouse model.
  • To elucidate the molecular mechanisms underlying miR-124's role in the prefrontal cortex (PFC).

Main Methods:

  • Comprehensive behavioral analysis of miR-124-1+/- mice.
  • Electrophysiological recordings in PFC slices.
  • Gene expression analysis of dopaminergic system components and glucocorticoid receptor.

Main Results:

  • miR-124-1+/- mice exhibited deficits in prepulse inhibition, social behavior, and increased hyperactivity.
  • Enhanced synaptic transmission was observed in PFC pyramidal cells of miR-124-1+/- mice.
  • Aberrant dopamine receptor D2 (Drd2) signaling and increased Nr3c1 expression were identified as key molecular changes.

Conclusions:

  • miR-124 dosage is critical for regulating PFC function.
  • miR-124 modulates PFC function by repressing the Drd2 pathway.
  • These findings highlight miR-124's essential role in maintaining normal brain function.