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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
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Anaphylactic Reaction to Tc-99m Macrosalb.
Nanno Schreuder1,2, Quincy de Hoog3, Wouter van der Bruggen4
1Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology and Economics, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands. n.schreuder@rug.nl.
Drug Safety - Case Reports
|March 7, 2019
Summary
A patient experienced a probable anaphylactic reaction to Tc-99m macrosalb during pulmonary scintigraphy. Prompt treatment led to full recovery, highlighting the need for vigilance with this diagnostic agent.
Area of Science:
- Nuclear Medicine
- Radiopharmacy
- Clinical Immunology
Background:
- Pulmonary scintigraphy is a common diagnostic procedure.
- Tc-99m macrosalb is a radiopharmaceutical used in this procedure.
- Adverse reactions to radiopharmaceuticals, though rare, can occur.
Purpose of the Study:
- To report a case of anaphylactic reaction to Tc-99m macrosalb.
- To assess the causality of the reaction using the Naranjo criteria.
- To emphasize the importance of recognizing and managing such adverse events.
Main Methods:
- A case report of a 49-year-old woman who developed symptoms shortly after Tc-99m macrosalb injection.
- Clinical observation of symptoms including itching, dyspnea, urticaria, and facial edema.
- Administration of clemastine and prednisone for treatment.
- Assessment of the reaction's probability using the Naranjo assessment algorithm.
Main Results:
- The patient experienced a rapid onset anaphylactic reaction post-injection.
- Symptoms included generalized itching, throat irritation, dyspnea, urticaria, and facial edema.
- The Naranjo assessment algorithm classified the reaction's relationship to Tc-99m macrosalb as 'probable'.
- The patient recovered fully after medical intervention.
Conclusions:
- Tc-99m macrosalb can precipitate anaphylactic reactions.
- Prompt recognition and management are crucial for patient safety.
- The Naranjo criteria support a probable link between the radiopharmaceutical and the adverse event.
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