The relationship between motor performance and femoral cartilage thickness in children with Down syndrome
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Updated: Jan 28, 2026

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Published on: May 19, 2023
Raikan Büyükavcı1, Mehmet Akif Büyükavcı2, Semra Aktürk3
1Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Inonu University, Malatya, Turkey. rsoydemir@yahoo.com.
Insights
Children with Down syndrome (DS) show a positive link between femoral cartilage thickness and gross motor skills. Thicker cartilage in the knee is associated with better motor development in young children with DS.
Area of Science:
- Pediatrics
- Genetics
- Orthopedics
Background:
- Down syndrome (DS) is a genetic condition impacting development.
- Motor delays are a common characteristic in children with DS.
- Understanding factors influencing motor development in DS is crucial.
Purpose of the Study:
- To examine the association between femoral cartilage thickness and motor performance in young children with Down syndrome.
- To determine if knee cartilage characteristics correlate with gross motor skills.
Main Methods:
- Ultrasound measurements of femoral cartilage thickness in both knees (medial, lateral, intercondylar areas).
- Assessment of gross motor skills using the Bayley Scales of Infant and Toddler Development III.
- Study included 39 children with DS aged 12-42 months.
Main Results:
- A significant positive correlation was found between femoral cartilage thickness and gross motor scaled scores in both knee joints.
- Specific correlation coefficients (r) ranged from 0.323 to 0.590 (p < .05).
- Increased femoral cartilage thickness was linked to better gross motor functioning.
Conclusions:
- Femoral cartilage thickness is positively correlated with gross motor functioning in children with Down syndrome.
- This finding may offer insights into the biomechanical factors affecting motor development in DS.
- Further research could explore interventions targeting cartilage health for motor improvement.
Abstract:
Down syndrome (DS) is a genetic disorder associated with mental and motor developmental delays in childhood. The aim of this study was to investigate the relationship of the femoral cartilage thickness with motor performance in children with Down syndrome (DS). A total of 39 children with DS in the age range of 12-42 months were included in the study (female/male: 21/18; mean age: 23.4 ± 8.2 months). Femoral cartilage thickness was measured with ultrasound in the medial and lateral condyles and intercondylar areas of both knees. Gross motor subtest scaled scores of the Bayley Scales of Infant and Toddler Development III were used for the motor performance assessment. There was a positive correlation between the gross motor scaled scores and the femoral cartilage thickness in both knee joints (p < .05; r = 0.415 for the right medial condyle; r = 0.323 for the right lateral condyle; r = 0.339 for the right intercondylar area; r = 0.369 for the left medial condyle; r = 0.364 for the left lateral condyle, and r = 0.590 for the left intercondylar area). The study demonstrated that the femoral cartilage thickness was positively correlated with gross motor functioning in children with DS.
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