Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.4K
Complementation Tests00:49

Complementation Tests

6.2K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.2K
Factors Affecting Activity Coefficient01:17

Factors Affecting Activity Coefficient

1.6K
The extended Debye-Hückel equation indicates that the activity coefficient of an ion in an aqueous solution at 25°C depends on three partially interdependent properties: the ionic strength of the solution, the charge of the ion, and the ion size. 
The activity coefficient value for an ion is close to one when the solution has almost zero ionic strength, i.e., when the solution shows close to ideal behavior. As the ionic strength of the solution increases from 0 to 0.1 mol/L, a...
1.6K
What is Variation?01:14

What is Variation?

18.4K
Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
18.4K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.8K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.8K
Variation01:19

Variation

8.0K
An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New insights into the pain of knee osteoarthritis: the characteristics of deep pain and abnormal central processing.

Sheng li xue bao : [Acta physiologica Sinica]·2026
Same author

Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer.

World journal of gastroenterology·2023
Same author

Collectin11 and Complement Activation in IgA Nephropathy.

Clinical journal of the American Society of Nephrology : CJASN·2021
Same author

The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage.

Journal of orthopaedic surgery (Hong Kong)·2020
Same author

MicroRNA-21-5p participates in IgA nephropathy by driving T helper cell polarization.

Journal of nephrology·2019
Same author

Dimeric ansamycins--a new class of antitumor Hsp90 modulators with prolonged inhibitory activity.

International journal of cancer·2006

Related Experiment Video

Updated: Jan 28, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K

Variation in complement factor H affects complement activation in immunoglobulin A vasculitis with nephritis.

Meng Jia1,2,3,4, Li Zhu1,2,3,4, Ya-Ling Zhai1,2,3,4

  • 1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Nephrology (Carlton, Vic.)
|March 7, 2019
PubMed
Summary
This summary is machine-generated.

The genetic variant rs6677604 in complement factor H influences complement activation in both Immunoglobulin A vasculitis with nephritis (IgAVN) and IgA nephropathy (IgAN). This variant may explain differences in complement activation intensity between these related diseases.

Keywords:
IgA nephropathycomplement activationcomplement factor Himmunoglobulin A vasculitis with nephritis

More Related Videos

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

9.4K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Related Experiment Videos

Last Updated: Jan 28, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K
Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

9.4K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Area of Science:

  • Nephrology
  • Immunology
  • Genetics

Background:

  • Immunoglobulin A vasculitis with nephritis (IgAVN) and IgA nephropathy (IgAN) are related kidney diseases with suspected complement system involvement.
  • A previously identified genetic variant, rs6677604 in complement factor H (CFH), is linked to IgA nephropathy (IgAN) susceptibility and complement activation.

Purpose of the Study:

  • To investigate the role of the rs6677604 genetic variant in complement activation within IgA vasculitis with nephritis (IgAVN).

Main Methods:

  • Genotyping of the rs6677604 variant in 632 IgAVN patients, 1178 IgAN patients, and 902 healthy controls.
  • Analysis of complement factor H (FH) and C3 levels, and assessment of glomerular C3 deposition intensity.

Main Results:

  • The rs6677604-A allele was more frequent in IgAVN patients compared to IgAN patients, but not different from controls.
  • Higher circulating FH levels were observed in IgAVN than IgAN, with a positive correlation between FH and C3 levels in IgAVN.
  • The rs6677604-A allele was associated with reduced glomerular C3 deposition in both IgAVN and IgAN, with less intense deposits in IgAVN.

Conclusions:

  • The CFH rs6677604 variant is implicated in the complement activation phenotype of both IgAVN and IgAN.
  • This genetic variation may contribute to the observed differences in complement activation intensity between IgAVN and IgAN.