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Updated: Jan 28, 2026

Capillary Electrophoresis to Monitor Peptide Grafting onto Chitosan Films in Real Time
Published on: October 26, 2016
Novel binary grafted chitosan nanocarrier for sustained release of curcumin
Deepak Kumar1, Vinit Raj2, Abhishek Verma3
1Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, U.P., India; Department of Applied Chemistry, M J P Rohilkhand University, Bareilly 243006, U.P., India.
Abstract:
The study deals with the synthesis and characterization of chitosan-g-Poly (Acrylic acid-co-Acrylamide) [chit-g-Poly (AA-co-Am)] for sustained release of curcumin. The formation of chit-g-Poly (AA-co-Am) was ascertained through various spectral, thermal, microscopic methods and zeta potential. The potential of chit-g-Poly (AA-co-Am) for drug delivery applications were investigated through pH regulated kinetic models, in vitro antibacterial assay and molecular docking studies. The study reveals antibacterial activity of chit-g-Poly (AA-co-Am) against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa along with enhanced binding with bacterial receptors. In this study, nanoparticle of curcumin drug with grafted chitosan (NpCGC) was developed as effective nano therapeutic drug delivery system. Kinetic data of NpCGC reveals that the enhanced release of curcumin from NpCGC has been occurred at pH 5.4. The present study provides an economical and eco-friendly approach towards the preparation of chit-g-Poly (AA-co-Am) for sustained drug delivery applications.
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