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Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy
Esther Latres1, Daniel A Finan1, Julia L Greenstein1
1JDRF, New York, NY 10004, USA.
Cell Metabolism
|March 7, 2019
Summary
Artificial pancreas systems and cell replacement therapies offer hope for normalizing glucose levels in people with diabetes. This review explores the challenges and opportunities for both innovative approaches to diabetes management.
Area of Science:
- Endocrinology
- Biomedical Engineering
- Regenerative Medicine
Background:
- Significant advancements in diabetes care include improved insulin formulations, continuous glucose monitoring, and artificial pancreas systems.
- Cell replacement therapy via transplantation shows promise but faces limitations due to donor supply and immunosuppression requirements.
- Despite progress, a small percentage of diabetes patients achieve glycemic control, highlighting the need for improved therapeutic strategies.
Purpose of the Study:
- To review the current state and future potential of artificial pancreas systems for diabetes management.
- To examine the progress and challenges in cell replacement therapies for diabetes.
- To compare the feasibility and opportunities of both approaches in normalizing glucose levels for individuals with diabetes.
Main Methods:
- Review of recent literature on artificial pancreas technology and cell transplantation for diabetes.
- Analysis of regulatory approvals and clinical outcomes of existing and emerging diabetes therapies.
- Discussion of the barriers and potential solutions for widespread implementation of cell therapy.
Main Results:
- Artificial pancreas systems have seen regulatory approval, but widespread glycemic goal achievement remains a challenge.
- Cell therapy for diabetes holds promise but is hindered by donor availability and the need for long-term immunosuppression.
- Ongoing research is addressing barriers to cell therapy, aiming for broader clinical application.
Conclusions:
- Both artificial pancreas systems and cell replacement therapies are advancing, offering potential pathways to normalize glucose levels in diabetes.
- Overcoming challenges in technology integration and cell therapy logistics is crucial for future success.
- Further research and development are essential to realize the full potential of these approaches in diabetes treatment.
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