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Standard treatment and emerging drugs for managing synovial sarcoma: adult's and pediatric oncologist perspective
Giacomo G Baldi1, Daniel Orbach2, Rossella Bertulli3
1a "Sandro Pitigliani" Medical Oncology Department , Hospital of Prato , Prato , Italy.
Introduction:
in this review we discuss the standard of care for both pediatric and adult synovial sarcoma (SS), the prognostic differences between them, and the treatments available for localized and advanced diseases. We also overview the biology and the recent drugs under consideration in clinical trials on SS. Areas covered: we focus on new targeted therapies being investigated for advanced SS, especially anti-angiogenic drugs, and immunotherapy. We review all the published data and ongoing trials dedicated to SS or to soft tissue sarcoma in general, paying particular attention to the results obtained in SS patients. Expert opinion: we expect new treatment strategies to become available for SS in the near future. The ongoing and published trials on targeted therapies and immunotherapy mainly concern adult patients, but the somatic biology of pediatric SS has some similarities as in adult disease. A stronger cooperation between adult and pediatric oncologists in recent years has led to a more shared effort to find new treatment strategies for advanced SS patients, regardless of their age.
Insights
New treatments for synovial sarcoma (SS) are emerging, including targeted therapies and immunotherapy. Research is focusing on both pediatric and adult patients, aiming for improved outcomes in advanced disease.
Area of Science:
- Oncology
- Molecular Biology
- Clinical Trials
Background:
- Synovial sarcoma (SS) is a rare soft tissue sarcoma affecting both pediatric and adult populations.
- Standard of care and prognostic differences exist between pediatric and adult SS.
- Current treatment options for localized and advanced SS are limited.
Purpose of the Study:
- To review the standard of care for pediatric and adult synovial sarcoma.
- To discuss available treatments for localized and advanced SS.
- To overview the biology and emerging targeted therapies and immunotherapies for SS.
Main Methods:
- Comprehensive review of published data on synovial sarcoma.
- Analysis of ongoing clinical trials for SS and soft tissue sarcomas.
- Focus on targeted therapies, including anti-angiogenic drugs, and immunotherapy.
Main Results:
- New targeted therapies and immunotherapies are under investigation for advanced SS.
- Clinical trials primarily focus on adult patients, but pediatric SS shares biological similarities.
- A collaborative approach between adult and pediatric oncologists is driving new treatment strategies.
Conclusions:
- Novel treatment strategies for synovial sarcoma are anticipated in the near future.
- Targeted therapies and immunotherapy show promise for advanced SS.
- Age-independent treatment strategies are being developed through increased collaboration.