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Updated: Jan 28, 2026
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Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
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Shift Work Patterns, Chronotype, and Epithelial Ovarian Cancer Risk
Lisa Leung1,2, Anne Grundy1,3, Jack Siemiatycki1,3
1Université de Montréal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Summary
Shift work is a probable carcinogen, but this study found no strong link to epithelial ovarian cancer (EOC) risk. However, morning chronotype individuals showed a potential increased risk with shift work exposure.
Area of Science:
- Epidemiology
- Occupational Health
- Oncology
Background:
- Circadian disruption from shift work is a probable carcinogen.
- Shift work may contribute to hormone-sensitive cancers.
- Investigated shift work and epithelial ovarian cancer (EOC) risk.
Purpose of the Study:
- To investigate the association between shift work exposure and epithelial ovarian cancer (EOC) risk.
- To explore potential modifying roles of chronotype and menopausal status.
Main Methods:
- Population-based case-control study (496 EOC cases, 906 controls).
- Collected lifetime occupational histories to assess shift work exposure.
- Used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- No clear pattern of increasing EOC risk with cumulative shift work years.
- The adjusted OR for EOC in the highest shift work category was 1.20 (95% CI, 0.89-1.63).
- A more pronounced association was observed in individuals with a "morning" chronotype (OR, 1.64; 95% CI, 1.01-2.65).
Conclusions:
- The study did not strongly demonstrate a relationship between shift work and EOC risk.
- Chronotype is an important factor to consider in shift work exposure studies.
- Further research may be needed to clarify the complex interplay between shift work, chronotype, and cancer risk.
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