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Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
Published on: October 14, 2021
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Sensing of physiological regulators by innate lymphoid cells
Cyril Seillet1,2, Nicolas Jacquelot3,4
1Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia. seillet@wehi.edu.au.
Cellular & Molecular Immunology
|March 8, 2019
Summary
Innate lymphoid cells (ILCs) sense physiological signals, integrating them to maintain tissue homeostasis and immune responses. Dysregulation of ILCs by physiological factors can lead to harmful immune alterations.
Area of Science:
- Immunology
- Physiology
- Cell Biology
Background:
- Homeostasis and immune protection depend on coordinated physiological systems.
- Bidirectional communication between immune and physiological systems is vital for restoring equilibrium.
- Innate lymphoid cells (ILCs) are key immune sentinels.
Purpose of the Study:
- To investigate the role of physiological signals in regulating innate lymphoid cells (ILCs).
- To understand how ILCs integrate intrinsic and extrinsic signals for immune and homeostatic functions.
- To explore the consequences of disrupted ILC regulation by physiological mediators.
Main Methods:
- Transcriptomic analyses of innate lymphoid cells (ILCs) from various tissues.
- Identification of receptors on ILCs for neuropeptides, hormones, and metabolic signals.
- Assessment of ILC effector functions and constitutive mediator secretion.
Main Results:
- ILCs express diverse receptors recognizing neuropeptides, hormones, and metabolic signals.
- ILCs rapidly secrete effector cytokines for immune responses and constitutive mediators for homeostasis.
- ILCs integrate intrinsic and extrinsic signals to modulate their activity.
Conclusions:
- ILCs play a critical role in sensing and responding to physiological cues.
- Proper regulation of ILCs by physiological mediators is essential for protective immunity and tissue homeostasis.
- Disruption in ILC regulation by physiological factors can result in detrimental immune responses.
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