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Updated: Jan 28, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ni-catalysed reductive arylalkylation of unactivated alkenes
1National Laboratory for Physical Science at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis , Hefei University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 20237 , P. R. China .
Abstract:
In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggest a reaction pathway with an intermediate reduction.
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